In this
chapter, we discuss statistical models for prognostication.
Our text aims to support researchers who intend to develop a
valid prognostic model based on clinical symptoms and other
patient characteristics.
This chapter
concentrates on the development and application of multivariable
regression models that provide predictions of an outcome. These
models include multiple predictor variables as registered in
individual patients.
We only
briefly discuss basic properties of regression models, which
can be found in detail in various textbooks (Altman,
1991) (Kleinbaum, 1998)
(Hosmer and Lemeshow, 1989).
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