Skip to Content
Interactive Textbook on Clinical Symptom Research Logo


Home Button

Clinical Research: Constipation Sections
Author Biography
Introduction
What is constipation?
Understanding the problem
Objective Measurement
Subjective Measurement
Measuring Components
Precipitating Factors
Currently Selected Section: Therapeutic Comparisons
Research Questions
Conclusion




Chapter 3: Methods for Clinical Research in Constipation: Therapeutic Comparisons
          

The crossover design brings with it problems of treatment interactions and order effects with or without a washout period, but these can also be taken into account statistically (Hills and Armitage, 1979).

Figure 8.1 Senna Lactulose
Graphic depiction of stool form in relation to laxative type, described in text.
Stool form in relation to laxative type and opioid type and dose - 95% confidence intervals are shown except for weak opioid results which are based on small numbers (lactulose/senna n = 4, codanthramer n = 3) (Sykes, 1991, with permission)

Figure 8.2 Senna Lactulose
Graphic depiction of stool frequency in relation to laxative type, described in text.
Stool frequency in relation to laxative type and opioid type and dose - 95% confidence intervals are shown except for weak opioid results which are based on small numbers (lactulose/senna n = 4, codanthramer n = 3) (Sykes, 1991, with permission)

Page 28 of 36
      Previous Page