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Clinical Research: Constipation Sections
Author Biography
Introduction
What is constipation?
Understanding the problem
Objective Measurement
Subjective Measurement
Measuring Components
Currently Selected Section: Precipitating Factors
Therapeutic Comparisons
Research Questions
Conclusion




Chapter 3: Methods for Clinical Research in Constipation: Precipitating Factors in Constipation
          

Somatization disorders may also be associated with constipation. It is part of the common experience of clinicians that some people spend a lifetime worrying about their bowels without apparent cause. This brings certain questions to mind:

  • Are constipated patients commonly psychologically abnormal?
  • Should psychological tests be included in the assessment battery for investigations of constipation?

The answer probably depends on two factors:

  • The length of the history of constipation.
  • The presence of accompanying illness factors which are associated with the onset of constipation.

Patients who have chronic complaints of constipation, but in whom no defect of intestinal function can be found, have been reported to contrast with those who have similar complaints but whose intestinal transit time is found to be extended. Compared with the slow transit patients, normal transit patients appear more likely to have an abnormal psychological profile in terms of:

Figure 7.1 Comparison of Proportions of Patients With Psychiatric History According to Confirmation of Diagnosis of Constipation (Ashraf et al., 1996)
Graphic depiction of constipation in psychiatric patients, with a much greater percentage of reporting no constipation, described in text.

Clearly the effective therapies might differ between the two populations of constipated patients, one centering on correction of bowel motility and the other on educational and behavioral techniques. Therefore, in a constipation study that was testing the efficacy of a mode of treatment, it might be important to know how many of each sort of patient was present in the group under investigation. Such a study would need both subjective and objective measures of constipation among its outcomes.

Note that we are considering here otherwise healthy people who have a chronic history of complaints of constipation. Among this group, patients with normal transit may be quite common (10 out of 25 in the study by Wald et al. Both groups had had symptoms for a mean of 10-15 years). Their symptoms may or may not be explained by abnormalities of defecation.

The situation among medically ill patients is different, in that few have previously had persistent problems with constipation. Those who have persistent problems can readily be identified by a screening question. Unpublished observations by the author show significant differences between palliative care patients’ reported rates of constipation before and after the onset of their illness.

Table 7.2
Frequency of constipation
Before illness Since illness
Always
4
23
More than half the time
7
27
Less than half the time
4
20
Rarely
34
15
Never
44
8
N = 93 (45 male, 48 female)

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