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Clinical Research: Constipation Sections
Author Biography
Introduction
What is constipation?
Understanding the problem
Objective Measurement
Subjective Measurement
Currently Selected Section: Measuring Components
Precipitating Factors
Therapeutic Comparisons
Research Questions
Conclusion




Chapter 3: Methods for Clinical Research in Constipation: Measuring Compnents - Slow Transit vs. Evacuation Delay
 

Anal manometry

Anal manometry is distinct from defecography or EMG in that it specifically measures the function of the anal sphincter, not of the pelvic floor muscles. The resting anal pressure is a measure of internal sphincter function, and the squeeze pressure is indicative of the function of the external sphincter. The pressures exerted by the sphincters can be measured by a water-filled balloon or by a transducer-tipped catheter, with a variety of techniques being used. However, unless the technique is carefully controlled, it is not possible to compare the results of different studies (Miller et al., 1988). Anatomical sphincter abnormalities can be assessed directly by anal endosonography, but the correlation of the findings with function is not necessarily strong (Schafer et al., 1997).

The integrity of the distal colonic myenteric nervous system can be demonstrated by a reflex fall in resting pressure in response to inflation of a balloon in the rectum; this reflex is absent in Hirschprung's Disease.

Rectal compliance

Rectal compliance is measured according to the volume to which a rectal balloon can be inflated before either the patient detects it or the desire to defecate is triggered. It is apparent that some chronically constipated people have significantly impaired rectal sensation (Bannister et al., 1986) and that sensation may also decline with age, putting the elderly at increased risk of fecal impaction (Read et al., 1985).

 

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