Chapter 26: Clinical Trials in Temporomandibular Disorders by Linda LaResche, ScD and Michael R. von Korff, ScD (TMD)


	Table of Contents

	Author Biographies
	Introduction
	Epidemiology
	The Population Perspective
	The Developmental Perspective
	The Ecological Perspective
	Epidemiologic Measures
	Defining a Case
	Pain Location
	Pain Frequency, Duration, and Severity
	Recency of Pain
	Ambient Pain or Pain on Function?
	Clinical Signs and Symptoms
	Pain Impact/Disability
	Co-Morbidity
	Choosing an Appropriate Design
	Cross-Sectional Surveys
	Longitudinal Studies
	Case-control Studies
	Prospective Designs
	Preventive and Clinical Trials
	Clinical Epidemiology
	Practical Considerations
	Sample Size
	Standardizing Data Collection
	Response Burden
	Summary