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Neural Mechanisms of Cardiac Pain
Author Biography
Introduction
Anterolateral System
Somatic vs. Visceral Nociceptive Processing
Angina Pectoris
Sympathetic Sensory Innervation
Currently selected section: Referred Pain
Vagal Sensory Innervation
Other Ascending Pathways
Central Sensitization
Thalamus and Cerebral Cortex
Neurophysiology of Angina Pectorsis
Nausea and Vomiting

Dyspnea
Summary

 

Chapter 25:Neural Mechanisms of Cardiac Pain: Referred Pain
        

Pain Referred to Somatic Structures

Neurophysiological observations support clinical experience showing that angina pectoris is most commonly felt in the proximal and axial regions of the left arm and chest and less frequently sensed further down the arm (Bennet et al, 1966; Sampson and Cheitlin, 1971; Sylven, 1989).

In animal studies, stimulating cardiac sympathetic afferent fibers strongly excites a majority of the spinothalamic tract cells with proximal somatic receptor fields, but only weakly excites a small portion of the cells with distal somatic input (Hobbs et al, 1992). Thus, a highly significant relationship exists between cells with excitatory visceral input and proximal axial fields.

Angina pectoris often mimics muscle pain in that both of these types of pain are described as deep, diffuse, dull and suffering. In contrast, cutaneous pain is usually sharp and localized. Similarities between muscle pain and cardiac pain are shown in patients suffering from angina pectoris (Lewis, 1942).

Patients compared pain provoked by a hypertonic saline solution injected into the paraspinal muscles of the left eighth cervical or first thoracic spinal segment with pain that was evoked during angina pectoris. These patients observed that the onset, continuation, segmental localization and character very closely mimicked anginal pectoris (Lewis, 1942).

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