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Clinical Trials in TMD Sections
Author Bio
Introduction
The Biopsychosocial Model
Designing Multicenter RCTs
Players in an RCT
Randomization
Trial Design Quality
TMD Case Definition
Endpoints and Outcome Measures
Currently selected section: Blinding & Masking
Study Sample Size
Number and Nature of Interventions
Study Length and Follow up
Intent-to-treat Analyses and Sample Size
Compliance
Multicenter RCTs
Implementing RCTs: Practical Issues
Analysis of TMD Trials
Conclusions
Acknowledgments
Appendix A
Appendix B

 

Chapter 22: Clinical Trials in Temporomandibular: Blinding and Masking
        

Double Blinding and TMD

Double blinding, or more specifically, masking both the patient and the provider/observer of that intervention that was given, has also been shown to be important, and have a strong effect on the treatment outcome. Ideally, neither the researcher-observer, treating clinician, patient, nor the statistician should know which treatment group a person was assigned.

Double-blind designs lend themselves well to drug studies in which identically packaged active drugs or substances are compared to inactive or placebo ingredients.

With TMD research, blinding can be problematic, since many of the interventions are not medications, and thus are not easy to mask or blind. If the study is about testing for the efficacy of occlusal splints, and the subject is not given one, it is difficult to mask this from the person providing treatment and the subject (Dao et al., 1994).


 


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