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Clinical Trials in TMD Sections
Author Bio
Introduction
Currently selected section: The Biopsychosocial Model
Designing Multicenter RCTs
Players in an RCT
Randomization
Trial Design Quality
TMD Case Definition
Endpoints and Outcome Measures
Blinding & Masking
Study Sample Size
Number and Nature of Interventions
Study Length and Follow up
Intent-to-treat Analyses and Sample Size
Compliance
Multicenter RCTs
Implementing RCTs: Practical Issues
Analysis of TMD Trials
Conclusions
Acknowledgments
Appendix A
Appendix B

 

Chapter 22: Clinical Trials in Temporomandibular: The Biopsychosocial Model
        

TMD may be viewed as a complex, chronic pain condition with multiple contributing factors that include among them (Epker and Gatchel, 2000):

  • The state of the physical structures such as the masticatory muscles, teeth, and the temporomandibular joint;
  • Personal oral parafunctional behaviors such as bruxism or clenching;
  • Psychological status, including anxiety, depression, somatization, and psychosocial functioning;
  • Ability to work;
  • Use of medications; and
  • Treatment seeking.

According to this conceptualization, TMD is currently best described by using a biopsychosocial model for this condition.

The most relevant factors in this biopsychosocial model of chronic pain relate to the view that TMD is a chronic, fluctuating condition that is predominately manifested by the report of pain. It is pain that overwhelmingly drives people to seek TMD treatment, and it is pain that is the principal outcome measure by which treatment is viewed as successful or not, as evaluated by both the patient and by TMD health care providers. Whether the cause of pain is from physical trauma or an upset of normal physiologic processes from daily stressors, either can generate subjective symptoms of pain and discomfort anywhere in the body.

Other chapters in this textbook dealing with symptomatic conditions for which people seek treatment, such as irritable bowel syndrome, are further examples of conditions that have been informed by the biopsychosocial perspective (see Chapter 16, by Kroenke and Gale, Somatization and Symptom Evaluation, this volume).

Chronic conditions are, by definition, resistant to "cure" in the usual sense of permanent elimination of signs and symptoms. The general understanding has emerged that an alternative, rehabilitation approach is more suitable for the design and implementation of treatment management interventions (Gallagher, 1999). Such a rehabilitative approach is universally understood to be central to the management of all chronic conditions in which persistent pain is a critical factor, including tension headache, common back pain, fibromyalgia, and irritable bowel syndrome.

In contrast, with a curative approach, an outcome to confirm the usefulness of a treatment intervention might be permanent elimination and reversal of all signs and symptoms. Considering well-known examples from dentistry, surgical extraction of an abscessed tooth "cures" a single manifestation of toothache pain and underlying pathologic infection.

On the other hand, periodontal surgery, per se, is not viewed as an absolute cure for much of periodontal disease, an acknowledged chronic dental disease which requires a more complex disease and illness model that integrates several treatment modalities--surgery, medication, behavior change-to rehabilitate and then maintain the health of the involved periodontal structures. As such, periodontal disease is also best described by a biopsychosocial model.

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