Because behavior
in response to pain can vary with the physical location of the
pain, the pain stimuli in any experiment should be introduced
in the same approximate location as the clinical phenomenon
being modeled. Safety aspects, of course, must be kept in mind.
Anatomical structures such as blood vessels or nerves that lie
in the experimental area may constrain options because their
manipulation or damage would pose unacceptable risks.
| Figure
9.1: Anatomical Location to Induce Pain
|
|---|
|
| The
anatomical location at which pain is induced
is studied using cadaver material. Illustration
shows a frontal section of the right jaw (masseter)
muscle with infusion needle in place. |
|
|
Although much of
what is presented later in this chapter is relevant for the
design of pain models in general, the following discussion focuses
on modeling the clinical entity referred to as temporomandibular
joint diseases and disorders (TMJD).