Question 6.2

Which one of the following statements is true?

Noxious thermal and electrical pulses, the intra-dermal injection of capsaicin, and the intramuscular infusion of saline or third molar extractions are valid model systems for the study of all clinical conditions involving pain.

Unlike for pain stimuli of brief duration during which subjects' pain perception is primarily captured by sensory descriptors (e.g. aching, throbbing, radiating), prolonged and sustained pain stimuli induce significant pain affect.

A pain challenge applied to superficial tissue, such as skin, is appealing due to the obvious experimental convenience and clinical relevance.

Time in pain minimally influences the subject's physiological state and response behavior.

A noxious stimulus of a given magnitude induces similar bio-behavioral effects in healthy subjects.