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Human Experimental Pain Models
Author Bios
Learning Objectives
Clinical Significance and Phenomenology
Complex Diseases: Need to Simplify
Model Requirements
Brief and Sustained Experimental Pain
Choice of the Pain Stimulus
A Model Design for Pain Experimentation
Experiential Adjustment
Choice of Stimulation Site
Stimulation Site for a Study of TMJD
Experimental Design
Model Validation: Level 1
Model Validation: Level 2
Model Validation: Level 3
Model Validation: An Example
Cross-Validation with Other Model Systems
Model Systems as Tools
Sample Size Estimation
Potential Difficulties
Currently selected section: Conclusion

 

Chapter 21: Human Experimental Pain Models: Conclusion
        

Question 20.2: Answer

Because subjects differ in their sensitivity to and suppression of pain both inter-individually as intra-individually with time in pain, regulatory processes are best studied by standardizing the experiential response for all study participants. Using an experiential approach, differences in regulatory mechanisms among subjects with different trait characteristics are assessed in the situation of a matched experience of pain, such as a given level of pain intensity. Pain-sensitive subjects are those who require a low stimulation rate (blue line) to reach and maintain a given experiential response (red line). On the other hand, pain-insensitive subjects are the opposite with respect to the stimulation rate required.

 

Figure 20.2 Pain Intensity and Stimulation Rate
Graphic depiction of pain intensity and stimulation rate, described in text.

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