|
We will conclude
this chapter with two questions designed to stimulate your thinking
and integrate some of the key points presented. Think carefully
about each question before clicking the "answer" button
to view the answer.
Question 20.1
What experimental model
technique is suitable to identify high and low pain responders
to brief deep pain stimuli?
Once subjects are classified
with respect to high and low pain responders, the investigators
are able to determine whether particular genotype and/or phenotype
characteristics explain the observed differences in pain sensitivity.
Question 20.2
What experimental model
design is useful to study pain-related regulatory effects in pain-sensitive
and pain-resistant subjects in a prolonged state of deep pain?
Once
responders are identified based on their stimulation requirements
versus time, secondary questions can focus on the extent to which
particular phenotype and/or genotype characteristics regulate
the subject's experiential response (Zubieta,
Smith et al., 2001; Zubieta, Smith et al., 2002; Zubieta, Heitzeg
et al., 2003).
|