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Model systems constitute
convenient research tools to probe questions that are difficult
to crack otherwise. They are particularly useful when disease
complexity makes it difficult to define study populations because
not all relevant factors can be controlled. In such situations,
a model system can become useful in reducing complexity so that
questions, as described below, can be studied in a simplified
context.
| Table
17.1: Type of Questions for Which Pain Model Systems
Can be Useful
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1.
What is the temporal sequence of events with respect
to the emergence of signs and symptoms?
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2.
What biological systems contribute to the development
of signs and symptoms?
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3.
What experimental conditions regulate the activity
of the involved biological systems?
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| 4.
What neural and/or molecular signals can be linked to
the emergence of signs and symptoms? |
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5.
What types of molecular and/or genetic make-ups influence
the symptom phenotype?
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