The North Central Cancer Treatment Group (NCCTG) has considerable experience with the development of clinical trials to evaluate means for alleviating hot flashes in women. The primary driver for this work is that hot flashes can be a major symptomatic problem in women at risk for, or with a history of, breast cancer. Estrogen therapy, which generally works quite well to alleviate hot flashes, is relatively contraindicated in such women. Starting back in the late 1990s, the Mayo Clinic and the NCCTG have developed and conducted a series of clinical trials evaluating new methods to alleviate hot flashes. These trials are summarized in Table 1.

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