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If such a conversion
is studied in only one direction, the tendency of pain to
worsen with cancer progression will tend to increase the
required dose and decrease the potency estimate of the second
drug.
You
answered:
Worsening
of painful lesions from progressive cancer may cause a dose
overestimate.
CORRECT
Worsening
of painful lesions from progressive cancer may cause an
overestimate of the dose of fentanyl needed to replace morphine
if one tries to extrapolate the estimate to a different
clinical situation, e.g. one is changing drugs in the opposite
direction, or if one is treating a nonprogressive pain condition.
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