Does this data suggest that amitriptyline doses approaching 150 mg are optimal for pain relief?

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This data does suggest the amitriptyline doses are optimal.

Even apart from the fact that there are too few points at the higher dose levels for statistical significance, individual titration designs have historically tended to give gross overestimates of effective dose levels. If a given dose produces an increasing effect over time, for example, it may appear that continued dose escalation is causing the improvement, when patients would have had similar improvement if they had stayed at a fixed low dose. For example, the recommended doses of many antihypertensives developed in the 1970’s were as much as ten times the true optimal level established by later studies in which patients were prospectively assigned to specific doses (Temple, 1989).

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