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Trial Design: Pain Sections
Author Bio
Introduction
Placebo Effects
Single Dose Trials
Repeated Dose Trials
Currently selected section:  Explanatory Versus Pragmatic
Dose-Response
Parallel Group Versus Crossover
Conclusion
 

Chapter 1: Clinical Trials of Pain Treatment: Explanatory Versus Pragmatic
 
 

Cartoon illustration of explanatory vs. pragmatic clinical trials, described in text.

The dichotomous explanatory/pragmatic schema is an oversimplification, of course. The investigator usually wishes to address both theoretical and practical concerns. This distinction may, however, offer a useful perspective for making design choices in complex cases
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