|
What
is a potential pitfall of this design?
You answered:
 A
positive control intervention that increases the sustained-release
opioid dose by 50% may not be large enough to produce significant
reductions in pain or dose of rescue medication.
INCORRECT
Perhaps.
A review of postoperative patient-controlled analgesia studies
(Max,
1994) found that only 3/15 treatments that augmented
total opioid dose by a median value of 50% showed a statistically
significant reduction in pain intensity or number of PCA
boluses. I know of no published studies in the chronic oral
dosing setting examining this question.
|