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Trial Design: Pain Sections
Author Bio
Introduction
Placebo Effects
Currently selected section: Single Dose Trials
Repeated Dose Trials
Explanatory Versus Pragmatic
Dose-Response
Parallel Group Versus Crossover
Conclusion
 

 

Chapter 1: Clinical Trials of Pain Treatment: Single Dose Trials: Question 3.6
         What can you conclude about Drug X efficacy?

You answered:


Selection BDrug X is an effective analgesic in these patients.

Treatments were drug X and morphine.  Drug X provided a large amount of pain relief, statistically superior to morphine.

CORRECT

Despite the absence of a placebo in this case, we can conclude that Drug X is an effective analgesic. Morphine was used as a standard analgesic because it was effective in previous studies in this condition. If Drug X is superior to morphine, it is almost certainly an effective analgesic as well. The fundamental principle of all of these cases is that interpretation of analgesic trials is straightforward if one shows a difference between at least two of the treatments

 

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