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Trial Design: Pain Sections
Author Bio
Introduction
Currently selected section: Placebo Effects
Single Dose Trials
Repeated Dose Trials
Explanatory Versus Pragmatic
Dose-Response
Parallel Group Versus Crossover
Conclusion
 

 

Chapter 1: Clinical Trials of Pain Treatment: Placebo Effects: Problem 2.2
 
       

What is your interpretation?

You answered:

Selection B   The magnitude of pain reduction is potentially useful, but the production of sedation by Compound G and not placebo unblinded the study. Compound G may be entirely without specific analgesic effects, the sedative side effects having biased patients towards reporting pain relief.

CORRECT

The placebo effect in pain studies may be so powerful that production of side effects by an otherwise ineffective drug might produce this modest level of pain relief. ( See Figure 2.1 and Figure 2.2 in the preceding text. )

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