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Trial Design: Pain Sections
Author Bio
Introduction
Placebo Effects
Single Dose Trials
Repeated Dose Trials
Explanatory Versus Pragmatic
Dose-Response
Currently selected section: Parallel Group Versus Crossover
Conclusion
 

 

Chapter 1: Clinical Trials of Pain Treatment: Parallel Group Versus Crossover Designs

 
           

Without having done the second study, could one have drawn the same conclusion? That is could one just display the 12/40 patients in the first trial with clonidine response surpassing placebo and infer that there is a clonidine-response subset?

You answered:  

Yes.

INCORRECT          

Even if a drug lacks any analgesic actions, many patients will have less pain during drug than placebo treatment by chance alone.

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