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Trial Design: Pain Sections
Author Bio
Introduction
Placebo Effects
Single Dose Trials
Repeated Dose Trials
Explanatory Versus Pragmatic
Dose-Response
Currently selected section: Parallel Group Versus Crossover
Conclusion
 

 

Chapter 1: Clinical Trials of Pain Treatment: Parallel Group Versus Crossover Designs

 
           

Would the use of a crossover design be likely to offer advantages over a parallel group design in comparing an antidepressant drug for the treatment of major depression to placebo?

You answered:

No.

CORRECT             

Psychiatrists studying depression do not use crossover designs because positive treatment responses are often of long duration, often persisting for months after the antidepressant drug is stopped (R Prien, 1994).

 

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