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Animal Models
In an effort to enact
research studies in a timely manner with no adverse effects on
human subjects, several species of animals such as the cat, dog,
rat, and ferret have been used in antiemetic studies with varying
degrees of success. The rat is a particularly inelegant model
as it is incapable of vomiting. A behavioral paradigm called "conditioned
taste aversion" or bait shyness has been suggested as an
analogue to nausea in the rat. As there is no way to directly
validate the appropriateness of this behavioral model as an analogue
to nausea, it remains an article of faith that taste aversion
in the rat is an analogue to nausea in man.
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